Hydrolysis of Substituted 3-(Thien-2-yl)imino-3H-furan-2-ones and Anti-Inflammatory Activity of the Reaction Products

Autor:	S. A. Shipilovskikh, Aleksandr E. Rubtsov, D. A. Shipilovskikh, R. R. Makhmudov
Rok vydání:	2021
Předmět:	Hydrolysis chemistry.chemical_compound Low toxicity Chemistry medicine.drug_class Furan Trifluoroacetic acid medicine heterocyclic compounds General Chemistry Medicinal chemistry Acute toxicity Anti-inflammatory
Zdroj:	Russian Journal of General Chemistry. 91:2025-2030
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363221100157
Popis:	The hydrolysis of substituted 3-(thien-2-yl)imino-3H-furan-2-ones in the presence of trifluoroacetic acid afforded a series of substituted 4-oxo-2-thienylaminobut-2-enoic acids. Anti-inflammatory activity and acute toxicity of the obtained substituted 4-oxo-2-thienylaminobut-2-enoic acids were studied. It was found that the obtained compounds have a pronounced anti-inflammatory activity and low toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f0fc6f67cabb97b7e6c0d8452ebbe5ad https://doi.org/10.1134/s1070363221100157 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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