Abstract 4814: Prediagnostic anthropometric measures and survival after diagnosis with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
| Autor: | Veronika Fedirko, H. Bas Bueno-de-Mesquita, Mazda Jenab, Elio Riboli, Anne Tjønneland, Tobias Pischon |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Gynecology
Cancer Research medicine.medical_specialty Colorectal cancer Proportional hazards model business.industry Hazard ratio Cancer Overweight medicine.disease Obesity European Prospective Investigation into Cancer and Nutrition Oncology Internal medicine medicine medicine.symptom business Body mass index |
| Zdroj: | Cancer Research. 73:4814-4814 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Background: Obesity is associated with increased colorectal cancer (CRC) risk, but very little research has been conducted to investigate the association between anthropometric factors and survival after CRC diagnosis. Methods: Therefore, we prospectively assessed the association between prediagnostic anthropometric measures [weight, height, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR)] with CRC-specific and overall mortality among 3,924 participants diagnosed with colorectal cancer (colon=2,462, rectum=1,462) between 1992 and 2008 in the EPIC cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) according to pre-defined categories and quintiles of anthropometric measures. Competing risk models were also utilized. Results: There were 1,309 deaths, 1,043 (80%) due to CRC. Mean follow-up after CRC diagnosis was 4 years. Being overweight (BMI=25-29.9 kg/m2) and obese (BMI≥30 kg/m2) was associated with increased CRC-specific mortality (HR=1.12, 95% CI, 0.97-1.30 and HR=1.26, 95% CI, 1.04-1.52, respectively; Ptrend=0.014) compared to normal weight patients (BMI Conclusions: Our preliminary results suggest that increased general obesity and central adiposity before diagnosis are associated with worse survival among Western European patients with CRC, but need to be confirmed in other studies. Citation Format: Veronika Fedirko, Elio Riboli, Tobias Pischon, Anne Tjønneland, H. Bas Bueno-de-Mesquita, Mazda Jenab, on behalf of the EPIC CRC Working Group. Prediagnostic anthropometric measures and survival after diagnosis with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4814. doi:10.1158/1538-7445.AM2013-4814 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|