Microwave Heated Continuous Flow Palladium(II)-Catalyzed Desulfitative Synthesis of Aryl Ketones
| Autor: | Jonas Sävmarker, Jonas Rydfjord, Bobo Skillinghaug, Mats Larhed |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Continuous flow Borosilicate glass Aryl Sodium Organic Chemistry Inorganic chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Physical and Theoretical Chemistry Microwave Aluminum oxide Palladium |
| Zdroj: | Organic Process Research & Development. 20:2005-2011 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.6b00306 |
| Popis: | A protocol for Pd(II)-catalyzed desulfitative synthesis of aryl ketones from sodium aryl sulfinates and nitriles in continuous flow has been developed. The reactions proceed with microwave heating using microwave transparent tube reactors, affording the desired aryl ketones in fair to good yields. Microwave transparent aluminum oxide reactors were identified as a safe and thermostable alternative to borosilicate glass reactors. |
| Databáze: | OpenAIRE |
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