Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents 2. Modification of the phenyl ring — the potentiating effect of fluorine substitution on in vivo activity
| Autor: | Betty H. Yagi, Suzanne E. Glickman, Susan K. Hendges, Ford Charles W, Toops Dana S, Jonda D. Schaadt, Barbachyn Michael R, Douglas Stapert, Kevin C. Grega, Jerry M. Buysse, Judith C. Hamel, James O. Kilburn, Gary E. Zurenko, William F. Demyan |
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| Rok vydání: | 1996 |
| Předmět: |
Stereochemistry
Organic Chemistry Clinical Biochemistry Pharmaceutical Science chemistry.chemical_element Ring (chemistry) Biochemistry Combinatorial chemistry In vitro chemistry.chemical_compound Meta chemistry In vivo Drug Discovery Fluorine Molecular Medicine Tropone Antibacterial activity Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:1009-1014 |
| ISSN: | 0960-894X |
| Popis: | Various electron-withdrawing groups were incorporated into the meta position of tropone-substituted 3-phenyl-2-oxazolidinones and their influence on antibacterial activity examined. Consideration of in vitro and in vivo test results indicated that one or two fluorine atoms flanking the para tropone appendage is the optimum arrangement for these compounds. Synthetic routes to enantiomerically enriched analogues are reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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