| Autor: |
Smita Kapoor, Yogendra Padwad |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Colon Cancer Diagnosis and Therapy ISBN: 9783030633684 |
| DOI: |
10.1007/978-3-030-63369-1_15 |
| Popis: |
Recent progress in understanding the interplay between tumor cells and immune cells has given emergence to a new field called immunotherapy. Tumor cells are dependent upon signals called “immune checkpoints” to escape themselves from immune surveillance. Despite the substantial advances in chemotherapy and radiotherapy, life expectancy of CRC patients has not been achieved successfully. Immunotherapy has recently emerged as a newfangled armor for combating cancer. Several immune checkpoint inhibitors have received approval from FDA for colon cancer treatment in clinical settings. The blocking of these checkpoints such as PD-1 or PDL-1 and CTLA-4 can help the immune system to fight against the tumor cells. Treatment with selective anti-PD-1/PDL-1 and anti-CTLA-4 monoclonal antibodies (mAbs) has revolutionized the therapeutic scenario of different cancer types. Advancements in combination chemotherapy regimens for colorectal cancer have led to significant improvement in disease-free survival. This chapter summarizes the rationale for immune checkpoint inhibitor therapy in colon cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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