| Autor: |
Mei Yu, Mo Wang, Hongtian Dong, Di Yun, Fang Huang, Dongxue Li, Xiaoshuang Zhang, Qing X. Li, Jinghui Wang, Jian Fei, Zhaolin Liu, Thomas Behnisch, Rong Fang, Zishan Wang, Yufang Yang, Chenye Shen |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| Popis: |
NRSF/REST plays an important role in the neuronal homeostasis as a transcriptional repressor of neuronal genes. NRSF/REST has been linked to cognitive preservation and longevity of humans, but its specific functions in age-dependent and Alzheimer's disease-related memory deficits remain unclear. In this study, we conditionally deleted NRSF/REST in the dorsal telencephalon or neurons of wild-type and APP/PS1 transgenic mice, and evaluated their cognitive abilities at different ages. The data indicated that conditional NRSF/REST-deficient mice had an age-dependently diminished retrieval performance in a variety of memory tests and altered hippocampal synaptic transmission and activity-dependent synaptic plasticity. In addition, the NRSF/REST deficient mice were characterized by an increase of activated glial cells, complement C3 protein, and the transcription factor C/EBPβ in the cortex and hippocampus. However, reduction of NRSF/REST in APP/PS1 mice by conditional depletion did not worsen the Aβ load and memory performance. The experiments suggest an important role of NRSF/REST for the maintenance of memory and synaptic plasticity in ageing mice, and point toward its potential roles in the onset of ageing-related memory impairments. Conditional NRSF/REST knockout mice of this study could be reliable experimental models of non-Alzheimer dementia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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