Synthesis of [14-14C] dexclamol hydrochloride and [14-14C] butaclamol hydrochloride
| Autor: | P. Raman, V. Ross, E. S. Ferdinandi |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Hydrochloride
Butaclamol Hydrochloride Organic Chemistry Optically active Biochemistry Analytical Chemistry chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery medicine Organic chemistry Radiology Nuclear Medicine and imaging Specific activity Spectroscopy Butaclamol medicine.drug Nuclear chemistry |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 14:757-765 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580140514 |
| Popis: | The synthesis of two [14C] labelled compounds, dexclamol and butaclamol hydrochloride, having the octahydrobenzocyclohepta pyridoisoquinoline structure is described. Both compounds were prepared by the same synthetic route starting from silver [14C]-cyanide and were labelled in the 14-position. Butaclamol (specific activity 1.23 mCi/mmole) was obtained in 13% overall yield while dexclamol (specific activity 17.8 mCi/mmole), an optically active compound requiring resolution in its preparation, was obtained in 2% overall yield. |
| Databáze: | OpenAIRE |
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