Personalized functional connectivity analysis in responders and nonresponders to ketamine and electroconvulsive therapy: A case series
| Autor: | Juan José Gonzalez, Leticia Fiorentini, Elsa Y. Costanzo, Marina Leiman, Maria Lucia Fazzito, Mirta F. Villarreal, Salvador M. Guinjoan, Adriana Pérez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Treatment response Series (stratigraphy) business.industry Functional connectivity medicine.medical_treatment medicine.disease 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health Clinical Psychology 0302 clinical medicine Electroconvulsive therapy Internal medicine Cardiology Medicine Major depressive disorder Antidepressant Ketamine Neurology (clinical) business 030217 neurology & neurosurgery Depression (differential diagnoses) medicine.drug |
| Zdroj: | Personalized Medicine in Psychiatry. :100082 |
| ISSN: | 2468-1717 |
| DOI: | 10.1016/j.pmip.2021.100082 |
| Popis: | Objective Major depressive disorder is a common medical problem, frequently resistant to antidepressant treatments. We sought to describe functional connectivity correlates of response and non-response to rapid-acting antidepressants in patients with treatment-resistant depression. Methods We performed an MRI-based, BOLD functional connectivity analysis on three patients with treatment-resistant depression, with varying degrees of response to electroconvulsive therapy (ECT) or intravenous subanesthetic ketamine. Results Response to treatment was associated with an increase of positive correlations and increased connectivity of bilateral frontal, subcortical, right temporal and right occipital regions. Treatment nonresponse was associated with an increase in negative correlations between frontal lobes and their respective contra- and ipsilateral parietal and occipital lobes. Conclusion Response to rapid-acting treatments was associated in this case series to increased functional connectivity, especially in homologous regions of both hemispheres. If replicated in a bigger sample, this correlate of response can provide insights into mechanisms of rapid-acting antidepressant treatment response. |
| Databáze: | OpenAIRE |
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