Anti-Inflammatory Activity of 2,4-Dinitrophenol following Local Administration at the Site of Inflammation
| Autor: | R. DeMeo, Goldstein S, Shemano I |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
inorganic chemicals
medicine.drug_class Chemistry Inflammation Oxidative phosphorylation Pharmacology General Biochemistry Genetics and Molecular Biology Anti-inflammatory In vitro 2 4-Dinitrophenol chemistry.chemical_compound Anesthesia medicine Dinitrophenol Phenylbutazone medicine.symptom Paw edema medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 128:980-982 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-128-33173 |
| Popis: | Summary2,4-Dinitrophenol was tested for local anti-inflammatory activity at the site of inflammation using the carrageenin-induced paw edema as an experimental model of inflammation. This compound was active only at or near lethal doses. Although dinitrophenol, compared to phenylbutazone, appears to be a more potent uncoupler of oxidative phosphorylation in vitro, it was less active on a milligram basis as an anti-inflammatory compound against the carrageenin-induced paw edema when administered locally at the site of inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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