Reactivity of anti-macrophage monoclonal antibody D11 in human leukemia and malignant lymphoma

Autor: Natalia A. Probatova, V. S. Poltoranina, Marina A. Frenkel, T. N. Zabotina, Sholokhova En, Natalia B. Lebedeva, Tatjana D. Rudinskaya, Tupitsyn Nn, Ljudmila Ya. Shipova
Rok vydání: 1996
Předmět:
Zdroj: International Journal of Cancer. 68:160-163
ISSN: 1097-0215
0020-7136
Popis: We have studied the reactivity patterns of a previously described pan-macrophage monoclonal antibody (MAb) D11 in 324 cases of acute leukemia and malignant lymphoma (ML). Reaction of D11 in tissue sections was restricted to histiocytes and macrophages. In non-Hodgkin's ML, D11 helped to confirm or to establish the histiocytic nature in 8 of 96 cases, i.e., in 4 of 6 histiocytic MLs; 2 of 13 anaplastic large-cell lymphomas; 1 of 4 large-cell immunoblastic clear-cell MLs; and 1 of 2 histiocytosis X cases. Positive reaction of D11 in acute lymphoblastic leukaemia (ALL) was found in 9 of 86 cases (all belonging to early B-lineage leukemia), of which 4 were CD34-positive and 5 co-expressed 1 or more myeloid/monocytic antigens. MAb D11 did not react in 42 cases of acute-myeloblastic-leukemia (AML) FAB variants M0-M5, except 1 acute mixed-lineage leukemia M1/pre-pre-B. Comparative study of the MAb D11 and a standard CD68 MAb KP- 1 showed that the antigens belong to different epitopes of different molecules.
Databáze: OpenAIRE
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