Synthesis, crystal structures, molecular docking and urease inhibition studies of Ni(II) and Cu(II) Schiff base complexes
| Autor: | Mahesh Kumar Mishra, S.R. Sharma, K. Ahmad, S. Sangeeta, Mukesh Choudhary, N. Noorussabah, Sulakshna Bharti |
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| Rok vydání: | 2018 |
| Předmět: |
Thermogravimetric analysis
Schiff base Urease biology 010405 organic chemistry Stereochemistry Acetohydroxamic acid Organic Chemistry Crystal structure AutoDock 010402 general chemistry 01 natural sciences Fluorescence spectroscopy 0104 chemical sciences Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound chemistry Docking (molecular) medicine biology.protein Spectroscopy medicine.drug |
| Zdroj: | Journal of Molecular Structure. 1156:1-11 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2017.11.062 |
| Popis: | [Ni(L)2] 1 and [Cu(L)2] 2 [HL = 2-((E)-(2-methoxyphenylimino)methyl)-4,6-dichlorophenol] Schiff base complexes have been successfully synthesized and were characterized by FT-IR, UV–Vis, fluorescence spectroscopy and thermogravimetric analysis. The crystal structures of the two complexes were determined through X-ray crystallography. Its inhibitory activity against Helicobacter pylori urease was evaluated in vitro and showed strong inhibitory activity against H. pylori urease compared with acetohydroxamic acid (IC50 = 42.12 μmolL−1), which is a positive reference. A docking analysis using the AutoDock 4.0 program could explain the inhibitory activity of the complex against urease. |
| Databáze: | OpenAIRE |
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