NEUROTOXICOLOGICAL PROPERTIES OF THE COMPOUND AV-19 FOR PROPHYLAXIS AND TREATMENT OF COMPLICATIONS OF DIABETES MELLITUS
| Autor: | Alexander A. Spasov, S. K. Kotovskaya, Vladimir L. Rusinov, V. A. Kosolapov, K. T. Sultanova, M. V. Miroshnikov, Irina M. Sapozhnikova, D. V. Mal’tsev |
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| Rok vydání: | 2020 |
| Předmět: |
business.industry
Sedation 04 agricultural and veterinary sciences 010501 environmental sciences Hypothermia Pharmacology medicine.disease 040401 food science 01 natural sciences Effective dose (pharmacology) Tachypnea Muscle tone 0404 agricultural biotechnology medicine.anatomical_structure Glycation Diabetes mellitus medicine medicine.symptom business ED50 0105 earth and related environmental sciences |
| Zdroj: | Toxicological Review. :39-43 |
| ISSN: | 0869-7922 |
| Popis: | The article presents the results of a study of the neurotoxicological profile of the new compound AB-19, acting on collagen glycation end products (AGE) and their receptors (RAGE), for the prevention and treatment of diabetes complications. The multi-test method «S. Irwin» was used. The test results were evaluated in parallel groups receiving the substance in doses starting with the average effective dose (ED50) and with a multiple increase by 5, 10, 20 and 50 times. It was found that the compound AB-19 in doses of 20, 100 and 200 mg / kg does not affect the functional and behavioral status of animals. However, with an increase to 400 mg / kg, typical manifestations of intoxication were observed: a decrease in muscle tone, hypothermia, sedation, tachypnea. As a result of the study, it was revealed that the neurotoxicological properties of the compound AB-19 are characterized by dose-dependent activity. A minimum toxic dose of 400 mg / kg ≤ Tdmin ≤ 1000 mg / kg was also indicated. |
| Databáze: | OpenAIRE |
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