Carboxylation reaction of a highly functionalized vinylic anion: a case of unexpected stability and reactivity

Autor:	Neelakandha S. Mani, Sudip Basu, Josef Moravek, Laurent Gomez, Jiejun Wu, J. Guy Breitenbucher
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Carboxylation Organic Chemistry Drug Discovery Organic chemistry Reactivity (chemistry) Pyrazole Cck1 receptor Biochemistry Combinatorial chemistry Ion
Zdroj:	Tetrahedron Letters. 51:1110-1113
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2009.12.112
Popis:	Attempts to prepare JNJ 26273364, a highly functionalized pyrazole-based CCK1 receptor antagonist, using a carboxylation reaction led to a series of unexpected results. This work demonstrated the unique reactivity and stability of the highly functionalized Z-alkene functionality present around the pyrazole.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f0a1ac034eb0ea43283c05ab6c73b95f https://doi.org/10.1016/j.tetlet.2009.12.112 Zobrazit plný text záznamu Full Text from ScienceDirect