Male Germ Cell-Expressed Mouse Gene TAZ83 Encodes a Putative, Cysteine-rich Transmembrane Protein (cyritestin) Sharing Homologies with Snake Toxins and Sperm-Egg Fusion Proteins. (testis/spermatogenesis/protein family/disintegrins)

Autor:	Uwe A.O. Heinlein, Annette Senftleben, Lydia Lemaire, Sabine Wallat
Rok vydání:	1994
Předmět:	endocrine system Cell Biology Mouse Protein Biology Molecular biology Fusion protein Transmembrane protein Cell biology Gene product Complementary DNA Gene expression Gene Peptide sequence Developmental Biology
Zdroj:	Development, Growth and Differentiation. 36:49-58
ISSN:	1440-169X 0012-1592
DOI:	10.1111/j.1440-169x.1994.00049.x
Popis:	Data obtained by cloning of a mouse cDNA (TAZ83) are presented. Its corresponding gene is expressed in meiotic and haploid testicular germ cells. The gene encodes a putative, cysteine-rich transmembrane protein with a deduced molecular weight of 90 kilodaltons and an isoelectric point of 5.4. Cysteine patterns within the predicted amino acid sequence of the TAZ83 gene product (cyritestin, cysteine-rich, testicular) are highly conserved when compared to various snake toxins of the disintegrin metalloproteinase type. The cysteine pattern conservation between cyritestin and a guinea pig sperm-egg fusion protein suggests that TAZ83 codes for a mouse protein with comparable properties or function.
Databáze:	OpenAIRE
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