Acute and sub-acute toxicity study of aqueous extract of Pericopsis (Afrormosia) laxiflora (Benth.) on white albino rats

Autor:	Coulibaly Adama, Ouattara Abou, Golly Koffi Julien, Kone Monon, Ouattara Karamoko
Rok vydání:	2020
Předmět:	Pericopsis laxiflora Aqueous extract Pericopsis Traditional medicine biology business.industry Subacute toxicity biology.organism_classification Acute toxicity Red blood cell medicine.anatomical_structure Oral administration Toxicity medicine business
Zdroj:	Journal of Pharmacognosy and Phytochemistry. 9:22-25
ISSN:	2278-4136 2349-8234
Popis:	Many plants investigated elsewhere were found to contain toxic substances. The objective of this study is to evaluate acute and sub-acute toxicity of aqueous extract of Pericopsis laxiflora, plant traditionally used to treat different diseases in Cote d’Ivoire. Acute toxicity of aqueous extract was assessed at a dose of 5000 mg/kg bw. For sub-chronic toxicity testing, Wistar rats were orally administered with different dose of the plant extract for 28 days. There was no mortality reported or any toxicity signs including autonomic effects in animals administered orally. The weights of the rats of the different batches increased over the 28 days after oral administration of the aqueous extract. Aqueous extract of Pericopsis laxiflora is not likely to produce any severe toxic effects. However, prolonged oral administration at high dose may cause observable changes in biochemical parameters, in particular Red blood cell and Platelets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f09aa6eb5f359a2f63924cafc0b026b3 https://doi.org/10.22271/phyto.2020.v9.i6a.12905 Zobrazit plný text záznamu