Evaluation of the hepato-protective potential of Sarcocephalus latifolius leaf methanol extracts in paracetamol-induced liver damage of mice
| Autor: | II Ezeigbo, Chinaka O. Nwaehujor, Eridiong O. Onyenweaku, Onyeka V. Asuzu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Kidney Antioxidant Hematology medicine.medical_treatment Decoction Biology Pharmacology Malondialdehyde Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure chemistry In vivo Oral administration 030220 oncology & carcinogenesis Internal medicine medicine Liver function Anatomy |
| Zdroj: | Comparative Clinical Pathology. 25:1053-1059 |
| ISSN: | 1618-565X 1618-5641 |
| DOI: | 10.1007/s00580-016-2310-5 |
| Popis: | Sarcocephalus latifolius, the African peach, is one greatly cherished, eaten and widely distributed shrubs mainly in the closed woodland savannah, and has been used to treat diverse diseases in some African and Asia populations. In Southern Nigeria, ‘herbal doctors’ include its leaves in decoctions given to patients of varying degrees of suspected liver damage. However, there is no scientific substantiation of their claim and use in literature. To evaluate the possible hepato-protective activity of S. latifolius leaves extract in paracetamol-induced hepato-compromised animal model as information is lacking. Adult mice were for 3 consecutive days orally administered methanol extracts of S. latifolius (SLM) at doses below any that is toxic, or Silymarin reference standard (100 mg/kg) prior to a high oral dose of paracetamol (2000 mg/kg) to damage the liver. Sacrificed animals 12 h after paracetamol treatment were bled. Serum obtained from clotted blood was used to biochemically quantify liver function enzymes, total protein and bilirubin levels as well as perform in vivo antioxidant studies. No acutely toxic signs or deaths were seen following oral administration of SLM extract. Orally given SLM extract at low doses produced a significant reduction in liver enzyme markers against the reference, as well as dose-dependent decreases in antioxidant parameters and total protein levels (p < 0.05). Our results portend that SLM extract possesses hepato-protective and antioxidant activity in paracetamol-induced hepato-compromised mice without any obvious untoward kidney damages suggesting that its use in the management of the liver diseases may be appropriate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink