P335 ‘Lipid triad ‘ in patients with chronic pancreatitis in combination with arterial hypertension
| Autor: | Maria Derbak, Bogdan Halay, Emilia Arkhiy, Oxana Moscal, Lyubomyra B Prylypko, Olesya Horlenko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B biology business.industry Lipid metabolism Triad (anatomy) medicine.disease Comorbidity Gastroenterology Persistence (computer science) medicine.anatomical_structure Internal medicine medicine biology.protein Pancreatitis lipids (amino acids peptides and proteins) In patient business Cholesterol homeostasis |
| Zdroj: | Abstracts. |
| DOI: | 10.1136/archdischild-2019-epa.684 |
| Popis: | Introduction Modern scientific research in the field of medical knowledge has repeatedly confirmed that the issue of ‘comorbidity’ is becoming widespread. More and more rare occurrences of the mononozological course of various diseases and the further, the more often - variants of a comorbid or multi-morbid. Materials In order to achieve this goal, we carried out a general clinical, laboratory and instrumental examination of 102 patients with comorbid pathology of CP and GC that were in the hospital treatment of Khust district hospital during 2017–2018. The average age of the examined patient was 51 ± 10 years. Results Concerning the features of lipid metabolism, the results obtained by us confirm the presence of ‘lipid triad’ in patients with Chronic Pancreatitis (CP) in combination with Arterial Hypertension a generalized persistence of inflammatory changes at the level of vascular endothelium. It is difficult to say with certainty that the primary focus in the examined group of patients, or dislipoproteinemia against the background of an existing CP with AH, but it is possible to clearly state the imbalance in the system of lipid homeostasis, which ultimately changes the activity of all organs and systems. The results of the study, which reproduce the changes in Apolipoprotein levels, were as follows: in the main group, the concentration of Apo A1 decreased to 0.85 ± 0.11 g/l against 1.08 ± 0.12 g/l in the control group (p In addition to the absolute values of lipidogram rates, in order to assess the presence or potential risk of developing atherosclerotic vascular damage, the ratio of Apo B/Apo A1 and the atherogenicity index that were higher in the group of patients with CP and GC: Apo B/Apo A1 – 1, 77 ± 0.46 versus 0.92 ± 0.14 (in the control group (p Conclusion The results of the study carried out during the hospitalization period in the main group indicate an increase in concentrations of proatherogenic fractions of lipids and apolipoproteins (LDL, LPDH, Apo B) and reduction of anti-atherogenic (HDL, Apo A1). The atherogenicity index and the ratio of Apo B/Apo A1 was also the highest than the norm. Therefore, we can assume that dyslipidemic disorders, without of effective means of correction, will contribute to the progression of both - CP and AH. |
| Databáze: | OpenAIRE |
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