Cyclosporin release in vitro from capsulated preparations

Autor:	V. N. Baikova, V. L. Bagirova, S. E. Milkina, E. B. Nechaeva, M. V. Ledovskih, N. P. Sadtchikova, A. P. Arzamastsev
Rok vydání:	2006
Předmět:	Pharmacology End point Chromatography food.ingredient food Chemistry Cyclosporin a Drug Discovery Pharmacology toxicology Bioequivalence Dissolution Gelatin In vitro
Zdroj:	Pharmaceutical Chemistry Journal. 40:102-105
ISSN:	1573-9031 0091-150X
Popis:	Dissolution profiles of cyclosporin A available in the form of soft gelatin capsules from four manufacturers were studied and characterized by the similarity and dissimilarity coefficients. No similarity was found between the dissolution profiles of the original preparation and three generics, although the integral dissolution indices of all preparations at the end point (60 min) were quite comparable. Therefore, determination of the dissolution index alone does not provide adequate evaluation of the bioequivalence of generics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f08e3600a36632e6a7148f03f16dee9d https://doi.org/10.1007/s11094-006-0068-9 Zobrazit plný text záznamu Plný text ve formátu PDF