Structural and functional imaging for vascular targeted photodynamic therapy
| Autor: | Brian C. Wilson, Ying Gu, Buhong Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Fluorescence-lifetime imaging microscopy business.industry medicine.medical_treatment Photodynamic therapy Laser Speckle Imaging Blood flow Macular degeneration medicine.disease 01 natural sciences 010309 optics Functional imaging 030207 dermatology & venereal diseases 03 medical and health sciences Dorsal Skinfold Window Chamber Model 0302 clinical medicine medicine.anatomical_structure 0103 physical sciences medicine Medical physics business Blood vessel |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.2253802 |
| Popis: | Vascular targeted photodynamic therapy (V-PDT) has been widely used for the prevention or treatment of vascular-related diseases, such as localized prostate cancer, wet age-related macular degeneration, port wine stains, esophageal varices and bleeding gastrointestinal mucosal lesions. In this study, the fundamental mechanisms of vascular responses during and after V-PDT will be introduced. Based on the V-PDT treatment of blood vessels in dorsal skinfold window chamber model, the structural and functional imaging, which including white light microscopy, laser speckle imaging, singlet oxygen luminescence imaging, and fluorescence imaging for evaluating vascular damage will be presented, respectively. The results indicate that vessel constriction and blood flow dynamics could be considered as the crucial biomarkers for quantitative evaluation of vascular damage. In addition, future perspectives of non-invasive optical imaging for evaluating vascular damage of V-PDT will be discussed. |
| Databáze: | OpenAIRE |
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