Radioiodination and biological evaluation of mesalamine as a tracer for ulcerative colitis imaging
| Autor: | M. H. Sanad, H. M. Talaat, Ahmed S.M. Fouzy |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Chemistry 010403 inorganic & nuclear chemistry medicine.disease 01 natural sciences Ulcerative colitis Gastroenterology 0104 chemical sciences 03 medical and health sciences 0302 clinical medicine Internal medicine TRACER medicine 030211 gastroenterology & hepatology Physical and Theoretical Chemistry Biological evaluation |
| Zdroj: | Radiochimica Acta. 106:393-400 |
| ISSN: | 2193-3405 0033-8230 |
| DOI: | 10.1515/ract-2017-2840 |
| Popis: | This study aims to evaluate newly radioiodinated mesalamine (Mes) as a tracer for ulcerative colitis imaging. Mes was labeled with [125I] with chloramine-T (Ch-T) as the oxidizing agent. Labeling factors such as pH, reaction temperature, reaction time, substrate amount and oxidizing agent amount were investigated to optimize the radiochemical yield (98.5%). The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoreses and high performance liquid chromatography (HPLC). The biological distribution indicated that the radioiodinated mesalamine localization was highest (72.28%) in microbial model compared to normal mice (29.25%) at 120 min post injection. So, 125I-Mes could be considered as a new radiotracer for ulcerative colitis. |
| Databáze: | OpenAIRE |
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