| Popis: |
Mesenchymal lesions of the breast represent a rare, heterogeneous group of benign and malignant lesions. Most mesenchymal lesions occurring anywhere in the body have also been reported in the breast, the vast majority being of fibroblastic or myofibroblastic origin, reflecting the normal constituents of the breast parenchyma. Other mesenchymal lesions include those of vascular, lipomatous and muscle origin. These lesions resemble their extramammary counterparts, both histologically and immunophenotypically. Additionally, the molecular changes that characterize these extramammary mesenchymal lesions have also been identified in cases that affect the breast. Although the molecular characteristics have been described in most of these lesions, some, such as pseudoangiomatous stromal hyperplasia and hemangiomas, have not been identified. Since detailed discussion of all mesenchymal lesions of the breast is beyond the scope of this chapter, the focus will be on those lesions with identifiable molecular changes with a review of their histological and immunophenotypical profiles. |
