Utility of p-chloranilic Acid and 2,3 Dichloro-5,6-dicyano p-Benzoquinone (DDQ) for the Spectrophotometric Determination of Triamterene
| Autor: | Samah S. Abbas, N. A. El Ragehy, S. Z. El-khateeb |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Triamterene
medicine.diagnostic_test Chemistry Biochemistry (medical) Clinical Biochemistry Analytical chemistry Charge-transfer complex Biochemistry Chloride Benzoquinone Analytical Chemistry Absorbance chemistry.chemical_compound Chloranilic acid Spectrophotometry Electrochemistry medicine Methylene Spectroscopy medicine.drug |
| Zdroj: | Analytical Letters. 30:2045-2058 |
| ISSN: | 1532-236X 0003-2719 |
| DOI: | 10.1080/00032719708001720 |
| Popis: | Two simple and sensitive spectrophotometric procedures are suggested for analysis of triamterene. The first procedure is based on the reaction of triamterene with p-chloranilic acid (p-CA) in methylene chloride to form a highly stable coloured product, exhibiting maximum absorbance at λ 530 nm. Beer's law is obeyed in the range of 40–220 μg.ml−1 with a mean percentage accuracy of 99.98 ± 0.446. Limit of determination is 20 μg.ml−1. In the second procedure, the drug is determined via charge transfer complex formation with 2,3 dichloro-5,6-dicyano p-benzoquinone (DDQ) using methylene chloride as a solvent. Here the reaction product has two well defined maxima at 460 nm and 530 nm where each has been utilized for quantitative determination. Beer's law is obeyed in concentration ranges of 25–125 μg.ml−1 and 25–150 μg.ml−1 with mean percentage accuracies of 99.92 ± 0.449 and 100.00 ± 0.511 for both maxima. 460 and 530 nm. respectively. Limit of determination is 12.5 μg.ml−1 at both maxima. Optimum con... |
| Databáze: | OpenAIRE |
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