Radiochemical quality control of99mTc-labelled radiopharmaceuticals
| Autor: | D. Konstantinovska, T. Maksin, V. Jovanović, B. Zmbova, J. Čvorić |
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| Rok vydání: | 1980 |
| Předmět: |
Biodistribution
Chromatography Pertechnetate Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Pollution Thin-layer chromatography Analytical Chemistry Paper chromatography chemistry.chemical_compound Electrophoresis Nuclear Energy and Engineering chemistry Acetone Radiology Nuclear Medicine and imaging Chemical control Spectroscopy |
| Zdroj: | Journal of Radioanalytical Chemistry. 59:239-243 |
| ISSN: | 1588-2780 0134-0719 |
| DOI: | 10.1007/bf02516852 |
| Popis: | Two methods for the determination of radiochemical purity of preparations labeled with99mTc are described. Paper chromatography was used for separation of reduced99mTc and free pertechnetate from the labeled radiopharmaceutical. Whatman 3MM paper was used first with a acetone and then with 1N NaCl, as the mobile phase. Instant thin layer chromatography was performed for comparison. The electrophoretic method was also applied, using 0.05 M Na-acetate and 0.017 M NaCl. Biodistribution of99mTc-DMSA in the organs of experimental animals was followed in order to verify chemical control methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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