Diaminohexopyranosides as Ligands in Half-Sandwich Ruthenium(II), Rhodium(III), and Iridium(III) Complexes
| Autor: | Christian Fowelin, Patrick J. Bednarski, Jürgen Heck, Matthias Böge |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Organic Chemistry
chemistry.chemical_element Talose Nuclear magnetic resonance spectroscopy Medicinal chemistry Rhodium Ruthenium Stereocenter Inorganic Chemistry Metal Gulose chemistry.chemical_compound chemistry visual_art visual_art.visual_art_medium Organic chemistry Iridium Physical and Theoretical Chemistry |
| Zdroj: | Organometallics. 34:1507-1521 |
| ISSN: | 1520-6041 0276-7333 |
| DOI: | 10.1021/om5013117 |
| Popis: | The syntheses of methyl 2,3-diamino-4,6-O-benzylidene-2,3-dideoxy-α-d-hexopyranosides of glucose, mannose, gulose, and talose and methyl 2-amino-4,6-benzylidene-2,3-dideoxy-3-tosylamido-α-d-glucopyranoside are exhaustively presented, as well as their application as ligands in half-sandwich ruthenium(II), rhodium(III), and iridium(III) complexes. The complex formation occurs highly diastereoselectively, creating a stereogenic metal center. The molecular structures of the ligands and their complexes were investigated by X-ray structure analysis, NMR spectroscopy, polarimetry, and DFT methods. The diamino monosaccharide complexes have been subjected to antitumor activity studies. In vitro tests of a few ruthenium complexes against different cancer cell types showed antiproliferative activities 4–10 times lower than that of cisplatin. |
| Databáze: | OpenAIRE |
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