Treatment with histamine-type 2receptor antagonists and omeprazole increase the risk of diarrhoea in neonatal foals treated in intensive care units
| Autor: | E. Haggett, R. Campbell, Brett S. Tennent-Brown, L. Pantaleon, Noah D. Cohen, J. E. Axon, L. C. Sanchez, Martin Furr |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Neonatal intensive care unit Neonatal sepsis business.industry Incidence (epidemiology) Horse General Medicine medicine.disease digestive system diseases chemistry.chemical_compound chemistry Intensive care Internal medicine Medicine Risk factor business Intensive care medicine Omeprazole Histamine medicine.drug |
| Zdroj: | Equine Veterinary Journal. 44:80-86 |
| ISSN: | 0425-1644 |
| Popis: | Summary Reasons for performing study: The use of anti-ulcer medication in the neonatal intensive care unit (ICU) is common due to the concern for development of catastrophic gastric ulcer disease. In man, however, the use of acid-suppressive medication has been shown in some studies to be a substantial risk factor for the development of Clostridium difficile-associated diarrhoea (CDAD), bacteraemia and neonatal sepsis. Objective: The purpose of the study reported herein is to evaluate the influence of anti-ulcer medications on the development of diarrhoea in the neonatal foal. Hypothesis: The use of anti-ulcer medication does not alter the incidence of diarrhoea in foals treated in an ICU. Methods: The records of 1710 foals from 6 different equine hospitals were examined and the use of anti-ulcer drugs was recorded. The presence of in-hospital acquired diarrhoea, CDAD, Clostridium perfringens-associated diarrhoea, neonatal sepsis and salmonellosis were documented. In addition, the presence of gastric ulceration, duration of hospital stay and short-term outcome were examined. Results: The use of anti-ulcer medications increased the odds of in-hospital diarrhoea by 2.0 (95% CI 1.4–2.9; P |
| Databáze: | OpenAIRE |
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