Tetra N -heterocyclic carbene dinuclear silver(I) complexes as potential anticancer agents: Synthesis and in vitro anticancer studies
| Autor: | Loiy Elsir Ahmed Hassan, Abdul Majid, Mohamed B. Khadeer Ahamed, Tabinda Fatima, Mohamad Taleb-Agha, Mohd. R. Razali, Ashfaq Ahmad, Muhammad Iqbal, Rosenani A. Haque |
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| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Chemistry Stereochemistry Organic Chemistry 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry In vitro 0104 chemical sciences Inorganic Chemistry HeLa chemistry.chemical_compound Benzonitrile Cell culture Cancer cell Materials Chemistry Tetra Physical and Theoretical Chemistry Cytotoxicity Carbene |
| Zdroj: | Journal of Organometallic Chemistry. 853:122-135 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2017.10.045 |
| Popis: | Present study involves the synthesis and characterization of a newly designed tetrakis benzimidazolium salts, 1–5 and their respective tetra N-heterocyclic carbene (NHC) dinuclear silver(I) complexes, 6–10 with different terminal substituents that constructed from either cyclopentyl, benzyl, n-butyl, 2-methylene benzonitrile or n-decyl. These well characterized compounds were then tested for anticancer potential by determining their IC50 values and antiproliferative activity on HCT116, MCF-7 and HeLa cancer cell lines. Anticancer potential of these compounds was then determined by evaluating the mode of cytotoxicity of these novel compounds. Among the synthesized compounds, the proligand 5 and silver(I)-NHC complex, 10 having n-decyl substitution show selective antiproliferation activity against human colon cancer cell lines (HCT-116). All the complexes 6–10 and proligand 5 show moderate and strong antiproliferative activity against breast cancer and cervical cancer possibly by inhibiting colony formation and migration of cancer cells. |
| Databáze: | OpenAIRE |
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