Reaction of quinine, 9-epiquinine and their acetates in superacid in the presence of hydrogen peroxide: an access to new fluorhydrins and/or ketones

Autor:	Marie-Paule Jouannetaud, Jean-Claude Jacquesy, Vincent Chagnault
Rok vydání:	2006
Předmět:	chemistry.chemical_compound Quinine chemistry Cyclic ether Organic Chemistry Drug Discovery medicine Organic chemistry Superacid Hydrogen peroxide Biochemistry medicine.drug
Zdroj:	Tetrahedron Letters. 47:5723-5726
ISSN:	0040-4039
Popis:	In HF–SbF 5 , in the presence of H 2 O 2 (source of OH + equivalent) quinine 1a yields 10-keto derivatives 4a and 5a and cyclic ether 3 as the major product. In the same conditions 1b , 2a , and 2b give the 10-keto and 10-fluoro-3-hydroxy analogs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f0415426d4dc3f0d6a891375ccd7075f https://doi.org/10.1016/j.tetlet.2006.06.011 Zobrazit plný text záznamu Full Text from ScienceDirect