Preparation of Biomimetic Zwitterionic Core Cross-Linked Nanocarriers for Control Release of Bioactive Agents

Autor:	Yang Zhou, Guohua Jiang, Yin Wang, Sheng Wang, Xiaoguang Xi, Rijing Wang, Tao Wang, Ruanbing Hu, Xiaohong Wang, Xinke Sun
Rok vydání:	2013
Předmět:	Materials science Polymers and Plastics General Chemistry Combinatorial chemistry Controlled release Dithiothreitol chemistry.chemical_compound Dynamic light scattering chemistry Drug delivery Amphiphile Materials Chemistry Ceramics and Composites Copolymer Organic chemistry Reversible addition−fragmentation chain-transfer polymerization Nanocarriers
Zdroj:	Journal of Macromolecular Science, Part A. 50:644-652
ISSN:	1520-5738 1060-1325
DOI:	10.1080/10601325.2013.784569
Popis:	Biomimetic core cross-linked nanocarriers (CCL-NCs) with zwitterionic shell was constructed from an amphiphilic block copolymer poly(2-(dimethylamino) ethyl methacrylate-co-carboxybetaine)-b-polystyrene ((PDMAEMA-co-PCB)-b-PS) via mini-emulsion RAFT polymerization. CCL-NCs present in this report possess properties of redox-sensitivity, limited unspecific protein adsorptions and low cytotoxicity, which highly enhance their potential application in drug delivery. Morphology of CCL-NCs was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. The control release process has also been investigated under three different conditions with or without dithiothreitol (DTT) at pH 5.4, 6.5 and 7.4.
Databáze:	OpenAIRE
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