High resting coronary flow velocity predicts worse survival in chronic coronary syndromes
| Autor: | Q Ciampi, L Cortigiani, A Zagatina, N Gaibazzi, F Rigo, E Picano |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Heart Journal. 43 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehac544.080 |
| Popis: | Background Coronary flow velocity (CFV) in the mid-distal left anterior descending coronary artery (LAD) can be easily assessed with transthoracic echocardiography (TTE). Although high resting CFV is associated with a reduced coronary flow velocity reserve which is a predictor of poor outcome, the prognostic significance of resting CFV remains unknown. Aim To assess the relationship between resting CFV and outcome. Methods Out of 11,410 initially screened, we prospectively enrolled 10,023 patients (age 64±12 years, 5,902 men, left ventricular ejection fraction [LVEF] 58±10%) with chronic coronary syndromes referred for resting TTE and with interpretable CFV. Recruitment (years 2004–2020) involved 5 accredited laboratories, with inter-observer variability Results The feasibility of CFV was 95%. The mean CFV of LAD was 32±14 cm/s. By multivariable logistic regression analysis diabetes mellitus, prior myocardial infarction, lower LVEF and higher age, heart rate, and systolic blood pressure were associated with the highest quintile of CFV. During a mean follow-up of 4.6±3.7 years, 1,066 died. Mortality at 10-years was lowest (15%) in patients in the lowest quintile (≤24 cm/s) and highest (34%) in patients in the highest (≥38 cm/s) quintile of CFV. Age (HR 1.057, 95% CI 1.053–1.062; p Conclusion CFV imaging in mid-distal LAD is highly feasible with TTE. High resting CFV predicts worse survival in the long-term. Funding Acknowledgement Type of funding sources: None. |
| Databáze: | OpenAIRE |
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