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Publisher Summary In recent years, there is great advancement and achievement towards the production of therapeutic molecules, using plant cell cultures. This is possible because of better understanding of cell culture cultivating methods, and the accelerated pace of development and utilization of predictable and efficient processes that have emerged in recent times. As a result of these advances, yields of complex molecules, such as paclitaxel have increased rapidly and led to scale-up to commercial production in 75 kl bioreactors. Without doubt, such successful industrial application of plant cell culture technology trigger further research on the production of plant-derived active pharmaceutical compounds. Finally, the integration of newer technologies in plant cells, such as metabolic engineering, and better understanding of biochemical principles of scaling-up processes derived from suspension cell culture is anticipated to accelerate opportunities for commercializing the production of more useful therapeutic compounds. |
