Elevated Levels of IgG and IgG4 to Malassezia Allergens in Atopic Eczema Patients with IgE Reactivity to Malassezia
| Autor: | Annika Scheynius, Maria Tengvall Linder, Rob C. Aalberse, Catharina Johansson |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Allergy
Immunology medicine.disease_cause Immunoglobulin E Atopy Allergen Immunopathology parasitic diseases medicine Immunology and Allergy integumentary system medicine.diagnostic_test biology business.industry Radioallergosorbent test fungi food and beverages General Medicine biology.organism_classification medicine.disease body regions biology.protein Malassezia Antibody business |
| Zdroj: | International Archives of Allergy and Immunology. 135:93-100 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000080651 |
| Popis: | Background: The opportunistic yeast Malassezia is considered to be one of the factors that can contribute to atopic eczema (AE). Elevated serum IgE levels, T-cell proliferation and positive skin prick test (SPT) and atopy patch test (APT) reactions to Malassezia are found among AE patients. Methods: Sera from 127 AE patients, 14 patients with seborrheic dermatitis (SD) and 33 healthy controls were investigated for IgE and IgG4 to M. sympodialis extract and four recombinant Malassezia allergens; rMala s 1, rMala s 5, rMala s 6, and rMala s 9. In addition, IgG to the recombinant allergens was analyzed. The IgG and IgG4 levels were compared to IgE levels and in vivo reactions (SPT and APT) to Malassezia. Results: AE patients with serum IgE levels >0.35 kU/l to M. sympodialis extract had significantly higher IgG4 levels to M. sympodialis extract than AE patients without detectable serum IgE to M. sympodialis extract, SD patients and healthy controls. Among the AE patients with and without detectable serum IgE to M. sympodialis extract, respectively, there were no differences in IgG4 levels between patients with positive or negative in vivo reactions to M. sympodialis extract. IgG4 to the rMala s allergens was almost exclusively found among patients with IgE to the same allergen. Within the four tested rMala s allergens, most IgG4 reactions were found to rMala s 6, an allergen with homology to cyclophilin. Conclusions: Elevated serum IgG4 to M. sympodialis extract accompanies elevated serum IgE to the extract. This is further confirmed by the association between IgG/IgG4 and IgE to recombinant Malassezia allergens. |
| Databáze: | OpenAIRE |
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