New phosphonate-substituted tricarbocyanines and their interaction with bovine serum albumin

Autor:	Elena D. Matveeva, Marina V. Proskurnina, Alexey A. Kostyukov, V. V. Temnov, V. A. Kuzmin, Nikolay S. Zefirov, Irina A. Doroshenko, Tatiana D. Nekipelova, Eugene V. Radchenko, G. V. Golovina, Tatyana A. Podrugina, Vladimir A. Palyulin
Rok vydání:	2016
Předmět:	biology 010405 organic chemistry Chemistry Stereochemistry Complex formation General Chemistry 010402 general chemistry 01 natural sciences Fluorescence Phosphonate 0104 chemical sciences Cardiogreen chemistry.chemical_compound Polymer chemistry biology.protein Bovine serum albumin
Zdroj:	Doklady Chemistry. 470:264-267
ISSN:	1608-3113 0012-5008
Popis:	New tricarbocyanine dyes with phosphonate groups (2, 3) were synthesized and their binding constants to bovine serum albumin (BSA) were determined. The binding constants of the synthesized tricarbocyanines and cardiogreen (1) (K b ~ 105 M–1) are similar, indicating an insignificant contribution of the Coulomb interaction to the complex formation, which is determined by the polymethine chain interaction with BSA. The fluorescence lifetimes attest to the formation of two types of complexes: the lifetime of the dye complex with BSA with a major contribution (~80%) is 740–800 ps, and a lifetime of ~210 ps corresponds to the complex of dye aggregates with BSA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f0255deae0699cafa3363f4555bd610c https://doi.org/10.1134/s001250081609007x Zobrazit plný text záznamu Plný text ve formátu PDF