Prognostic value of hypoxia gene expression in bladder cancer patients

Autor:	Taeryool Koo, Hyun Chang, SooYoon Sung, Seung-Hyun Lee, Moon Ho Kim
Rok vydání:	2020
Předmět:	Cancer Research Bladder cancer Oncology business.industry Gene expression Cancer research Medicine Hypoxia (medical) medicine.symptom Gene signature business medicine.disease
Zdroj:	Journal of Clinical Oncology. 38:548-548
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2020.38.6_suppl.548
Popis:	548 Background: The prognostic value of hypoxia in bladder cancer remains unknown. We aimed to evaluate the potential role of hypoxia gene signature as prognostic factors in bladder cancer patients. Methods: We investigated the hypoxia gene signature and clinicopathologic features of The Cancer Genome Atlas (TCGA) bladder urothelial carcinoma (n = 408) using the Kaplan-Meier survival curves and multivariate Cox regression analyses. The clinicopathologic data and the processed data of hypoxia gene signature were obtained from TCGA Bladder urothelial carcinoma database. Results: Hypoxia gene signature score was significantly associated with overall survival (OS) and progression-free survival (PFS). Higher score resulted in shorter OS and PFS in Kaplan-Meier survival curves with Log-rank test ( P < 0.01 and P
Databáze:	OpenAIRE
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