| Autor: | Qi Wu, Yuan Chang Yan, Xiao Bing He, Jing Hua Hu, Shohei Koide |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Agonist
medicine.medical_specialty urogenital system medicine.drug_class GABAA receptor musculoskeletal neural and ocular physiology General Medicine Biology Bicuculline Biochemistry GABAA-rho receptor Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology nervous system chemistry Muscimol Internal medicine medicine Channel blocker Receptor Picrotoxin medicine.drug |
| Zdroj: | Neurochemical Research. 27:195-199 |
| ISSN: | 0364-3190 |
| DOI: | 10.1023/a:1014876303062 |
| Popis: | GABA triggers mammalian sperm acrosome reaction (AR). Here, evidence is presented, showing that rat spermatozoa contain GABAA receptors, composed of α5, β1 and β3 subunits. The effects of GABAA receptor agonist and antagonist on the induction of AR in rat spermatozoa were assessed using the chlortetracycline assay. Muscimol, a GABAA receptor agonist, triggered AR; whereas bicuculline, a GABAA receptor antagonist and picrotoxin, a GABAA receptor/Cl− channel blocker, inhibited the ability of GABA or progesterone to induce AR. In conclusion, GABAA receptors appear to mediate the action of progesterone in inducing AR in rat spermatozoa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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