Identification and characterization of microRNAs in white and black coated yak

Autor:	Guang-Xin E, Luobu Danjiu, Yan-Bin Zhu, Wang-Dui Basang, Xiao-Lin Luo, Shi-Cheng He, Tian-Wu An
Rok vydání:	2018
Předmět:	0301 basic medicine General Veterinary Wnt signaling pathway RNA-Seq Computational biology Transcriptome White (mutation) 03 medical and health sciences 030104 developmental biology microRNA Transcriptional regulation Animal Science and Zoology KEGG Gene
Zdroj:	Indian Journal of Animal Research.
ISSN:	0976-0555 0367-6722
Popis:	In this study, we used high-throughput technology to provide the first transcriptome dataset for differentially expressed miRNA in mixed pools of dermis tissue from black- and white-coated yak to research the possible molecular mechanisms of yak coat pigmentation. In this study, 92,636,002 and 95,917,842 clear reads were generated through Illumina paired-end sequencing. A total of 78 differentially expressed miRNAs (DEMs) were identified, including 59 upregulated and 19 downregulated miRNAs in the mixed pools of white-coated yak compared with the mixed pools of black-coated yak. In addition, 3634 genes were predicted as putative targets of DEMs. These DEGs related to 59 GO categories and were enriched in 216 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, including melanogenesis and the Wnt signaling pathway. The results of the current study indicated that the coat color of the yak involved the transcriptional regulation process of miRNAs. These results provide helpful data to understand the molecular mechanisms of yak coat pigmentation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f01bdc1e01448ddbb831c4387ae44fe8 https://doi.org/10.18805/ijar.b-834 Zobrazit plný text záznamu