Effect of Androgen Deficiency on the Human Meibomian Gland and Ocular Surface1
| Autor: | Jennifer M. Cermak, Reza Dana, David A. Sullivan, M. David Ullman, Dorothy Bazzinotti Tolls, James E. Evans, Kathleen L. Krenzer |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Chemistry Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Dry Eye Syndromes Meibomian gland medicine.disease Antiandrogen Biochemistry eye diseases body regions Endocrinology medicine.anatomical_structure Cornea Metaplasia Internal medicine Androgen deficiency medicine Tears sense organs medicine.symptom Antiandrogen Therapy |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 85:4874-4882 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | The purpose of this study was to determine whether the chronic use of antiandrogen medications leads to meibomian gland dysfunction, altered lipid profiles in meibomian gland secretions, decreased tear film stability, and evaporative dry eye. Subjects taking antiandrogen therapy for prostatic indications, as well as age-related controls, were asked to complete a questionnaire that assessed dry eye symptoms and then were given a complete anterior segment examination. Moreover, meibomian gland secretions were obtained from each eye and analyzed by high-performance liquid chromatography/mass spectrometry for the relative content of cholesterol, cholesterol esters, wax esters, diglycerides, triglycerides, and specific molecular species in the diglyceride fraction. Our results demonstrate that patients taking antiandrogen treatment, compared with age-related controls, had a: 1) significant increase in the frequency of appearance of tear film debris, an abnormal tear film meniscus, irregular posterior lid margins, conjunctival tarsal injection, and orifice metaplasia of the meibomian glands; 2) significant increase in the degree of ocular surface vital dye staining; 3) significant decrease in the tear film breakup time and quality of meibomian gland secretions; and 4) significant increase in the frequency of light sensitivity, painful eyes, and blurred vision. In addition, the use of antiandrogen pharmaceuticals was associated with significant changes in the relative amounts of lipids in meibomian gland secretions. Our findings indicate that chronic androgen deficiency is associated with meibomian gland dysfunction and dry eye. |
| Databáze: | OpenAIRE |
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