Screening of Antidotes from Natural Oriental Drugs for Botulinum Neurotoxin Type A

Autor:	Toshiaki Ishii, Eiki Satoh, Tetsuji Ohno, Iwao Sakane, Shin-ichi Sawamura, Masakazu Nishimura
Rok vydání:	2004
Předmět:	chemistry.chemical_classification Traditional medicine Botulinum Neurotoxin Type A medicine.medical_treatment medicine.disease Puerariae radix Botulinum neurotoxin chemistry Scutellariae radix medicine Tannin Botulism Antidote Black tea Food Science
Zdroj:	NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI. 51:463-466
ISSN:	1881-6681 1341-027X
Popis:	We prospected the antidotes from natural oriental drugs for botulinum neurotoxin type A. The crude extracts of Galla Rhois and Geranii Herba showed a potent antidote activity for botulinum neurotoxin type A. The antidote titer of the crude extracts of black tea was higher than those of Galla Rhois and Geranii Herba. No antidote activity was detected in the crude extracts of the followings: Gambir, Rosae Multiflorae Fructus, Scutellariae Radix, Coptidis Rhizoma, Sophorae Flos, Puerariae Radix, Houttuyniae Herba, Swertiae Herba, Galla Halepensis. Although both Galla Rhois and Galla Halepensis are gall-apples and contain tannin as the main component, Galla Rhois showed the potent antidote activity while Galla Halepensis did not.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f017ba74f6b21ea21929527976f5ada8 https://doi.org/10.3136/nskkk.51.463 Zobrazit plný text záznamu