| Popis: |
We read with great interest the recent review article in Trends in Immunology by Nandakumar and Holmdahl [1]. In this article, the authors raised the possibility of treating patients who have disease-inducing autoantibodies with bacterial proteases that cleave certain IgG subclasses into F(ab’)2 and Fc fragments. The idea behind this approach is to prevent Fc-dependent effector functions of target-bound IgG autoantibodies. The same authors earlier demonstrated that collagen antibody–induced arthritis can be blocked in mice by injecting recombinant IdeS, an IgG-degrading cysteine-protease from Streptococcus pyogenes, which specifically cleaves mouse IgG2a or c and IgG3 [2]. |
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