Synthesis and Antiproliferative Activity of Novel Hydrazono Thiazolidene and Thiazole Derivatives Bearing Rhodanine Moiety

Autor:	Abd El-Galil E. Amr, Mervat M. Omran, M. E. A. Elasasy, N. A. Abdel Hafez, Ashraf M. Mohamed, Mohammad E. Azab, Dina H. Elnaggar
Rok vydání:	2021
Předmět:	Chalcone Cancer General Chemistry medicine.disease Combinatorial chemistry chemistry.chemical_compound Rhodanine chemistry Cell culture Pyridine medicine Moiety Thiazole Malononitrile
Zdroj:	Russian Journal of General Chemistry. 91:915-925
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363221050236
Popis:	Some new fluoro-heterocyclic compounds containing thiazole and pyridine moities have been synthesized and studied for their antiproliferative activity. Thiazole derivatives have been synthesized by the reaction of alpha-halo carbonyl compounds with thiosemicarbazones. Some pyridine derivatives have been synthesized by the reaction of chalcone with cyanothioacetamide and/or malononitrile. Spectroscopic methods have been used for elucidating molecular structures of the products. Cytotoxic activity of several derivatives has been tested against human breast cancer (MCF-7), human colon cancer (HCT-116) and human liver cancer (Hep-G2) by the SRB method. Most of compounds exhibit mild effect on the tested cell lines. One of thiazolidin-4-one derivatives has been characterized by moderate to strong effect on MCF-7 cell line.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f00712401b79f205e9480548b129d7b6 https://doi.org/10.1134/s1070363221050236 Zobrazit plný text záznamu Plný text ve formátu PDF