Tetrasulfanes as Selective Modulators of the Cellular Thiolstat
| Autor: | Uma M. Viswanathan, Claus Jacob, Torsten Burkholz, Brigitte Czepukojc, Sher Ali, Ahsan Raza |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences Reactive oxygen species Antioxidant 010405 organic chemistry Chemistry medicine.medical_treatment Organic Chemistry Biological activity Polysulfane 01 natural sciences Biochemistry 0104 chemical sciences 3. Good health Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound Enzyme medicine 030304 developmental biology Cysteine |
| Zdroj: | Phosphorus, Sulfur, and Silicon and the Related Elements. 188:446-453 |
| ISSN: | 1563-5325 1042-6507 |
| DOI: | 10.1080/10426507.2012.746691 |
| Popis: | Naturally occurring polysulfanes often exhibit a wide spectrum of biological activity, which results from their ability to react with, and hence modify cysteine residues in key proteins and enzymes of the cellular thiolstat. Such interactions frequently proceed via S-thiolation of cysteine residues and subsequent formation of Reactive Oxygen Species. Polysulfanes are highly effective, yet also surprisingly selective for cysteine residues and enable the control of numerous cellular processes ranging from an activation of antioxidant defenses to the induction of programed cell death. Unfortunately, the arsenal of natural tri- and tetrasulfanes is limited. Here, we showcase the synthesis of asymmetric tetrasulfanes, which exhibit an interesting nematocidal activity and represent a new generation of tailor-made polysulfanes with potential applications in the field of agriculture and medicine. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus Sul... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|