Viral Inhibitors of Biological Origin. II. A Viral Inhibitory Factor Obtained from E. coli 0111 and Inhibition of Viral Replication by Nucleic Acid Derivatives
| Autor: | David H. Carver, Fred Rosen |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Corynebacterium diphtheriae
biology viruses medicine.disease_cause biology.organism_classification Virology General Biochemistry Genetics and Molecular Biology Virus Microbiology chemistry.chemical_compound Viral replication chemistry Cell culture medicine Nucleic acid Vaccinia Escherichia coli Bacteria |
| Zdroj: | Experimental Biology and Medicine. 116:575-579 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | Suppression of viral multiplication by crude materials derived from a variety of sonically disrupted bacteria has been described (1,2). The inhibitory material from each bacterial species tested suppressed certain viruses without affecting the multiplication of others. Thus, while arboviruses are inhibited by material derived from an unclassified Coryne-bacterium, ECHO 11 is suppressed by material from Corynebacterium diphtheriae (both non-toxigenic and intermedius strains) and vaccinia is suppressed by material derived from various Escherichia coli serotypes and Salmonella typhimurium. The present report is concerned with further characterization of the material from E. coli 0111, using the multiplication of vaccinia virus in primary human amnion cell cultures as an indicator system. Preliminary observations concerning viral inhibition by nucleic acid derivatives are also included in this report.Preparation. An inoculum of E. coli 0111, obtained from Dr. J. G. Michael, was grown in one liter of Bacto nut... |
| Databáze: | OpenAIRE |
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