Effect of age on cis-atracurium besylate pharmacokinetics following a single 1 mg kg–1 intravenous bolus in young pigs
| Autor: | Félix García, Anna Andaluz, C. Cristofol, Xavier Moll, Adrià Aguilar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
General Veterinary
Atracurium Besylate 040301 veterinary sciences business.industry Area under the curve 04 agricultural and veterinary sciences Intravenous bolus Laudanosine 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Elimination rate constant chemistry Pharmacokinetics 030202 anesthesiology Anesthesia Arterial blood Medicine business Distribution Volume |
| Zdroj: | Veterinary Anaesthesia and Analgesia. 46:643-651 |
| ISSN: | 1467-2987 |
| DOI: | 10.1016/j.vaa.2018.11.012 |
| Popis: | Objective To determine the cis-atracurium pharmacokinetic data and laudanosine production of a single 1 mg kg–1 cis-atracurium dose in the pig and to compare the pharmacokinetics between two groups of different ages. Study design Prospective experimental study. Animals Sixteen female pigs in two groups. Group A included eight animals aged 2.0–2.5 months and weighed 26.6 ± 3.6 kg. Group B included eight animals aged 4.0–5.0 months and weighed 57.4 ± 8.3 kg. Methods The pigs were anaesthetized and monitored throughout the procedure. Arterial blood samples collected at 0, 0.5, 1, 2, 5, 10, 20, 30, 45, 60, 90, 120 and 180 minutes after cis-atracurium injection were cooled and centrifuged. Plasma was acidified and stored at –20 °C for subsequent cis-atracurium and laudanosine analyses. Results Anaesthetic parameters were within normal ranges throughout the procedure. Plasma cis-atracurium and laudanosine concentrations were measured for the 16 pigs. Elimination rate constant, elimination half-life, area under the curve, mean residence time, distribution volume and total clearance were calculated for each pig. Statistical differences (p Conclusion and clinical relevance Longer duration of plasma cis-atracurium concentrations were observed in younger pigs. Distribution volume was also higher in younger pigs. Conversely, total clearance and area under the curve were similar between the two age groups. No laudanosine production was detected, suggesting a different cis-atracurium metabolism in the pig compared with other species. |
| Databáze: | OpenAIRE |
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