ChemInform Abstract: N-Aryl Heterocycles via Coupling Reactions with Arylboronic Acids

Autor:	Marina Lefort, Werner Mederski, Martina Germann, Dieter Kux
Rok vydání:	2010
Předmět:	Indole test chemistry.chemical_compound chemistry medicine.drug_mechanism_of_action Aryl Factor Xa Inhibitor medicine General Medicine Combinatorial chemistry Coupling reaction Pyrrole derivatives Pyrrole
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
Popis:	Compounds having a partial 2-pyridone structure or 3-pyridazinones can be selectively N-arylated with phenylboronic acids according to the procedure described by Chan and Lam. This procedure leads to N5-arylated imidazo[4,5-c]pyridin-4-ones, precursors of potent factor Xa inhibitors. In addition, the synthesis of N-aryl substituted pyrrole- and indole-2-carboxylic acid esters is described. In the indole series this procedure offers a flexible entry in the synthesis of different 1,3-diaryl-2-carboxyindoles.
Databáze:	OpenAIRE
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