About the possible role of endogenous modulators of β-adrenoreactivity and M-cholinoreactivity in the pathogenesis of asthma

Autor:	V. I. Tsirkin, I. V. Popova, E. N. Sizova, A. S. Vakhrusheva, T. N. Kononova
Rok vydání:	2007
Předmět:	Pulmonary and Respiratory Medicine Pathogenesis business.industry Immunology medicine Endogeny medicine.disease business Asthma
Zdroj:	PULMONOLOGIYA. :46-50
ISSN:	2541-9617 0869-0189
DOI:	10.18093/0869-0189-2007-0-5-46-50
Popis:	Ability of blood sera from 19 asthmatic children and 56 asthmatic adults to modify reactivity of β-adrenoreceptors and M-cholinoreceptors in isolated smooth muscles of the uterus horns from nonpregnant rats (n = 234) and cow trachea (n = 36) have shown that asthma presence did not change serum myocyte-stimulating activity but reduced the sensitizing activity of β-adrenoreceptors and the blocking activity of M-cholinoreceptors and enhanced the blocking activity of β-adrenoreceptors. The similar changes were also seen in child urine and indicated the decreased level of the endogenous sensitizer of β-adrenoreceptors and the growing level of the endogenous blocker of β-adrenoreceptors in asthma patients and the decreased level of endogenous blocker of M-cholinoreceptors in certain asthmatics. These events could provide asthma occurrence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eff55e0bf8928fa656075b29576bd229 https://doi.org/10.18093/0869-0189-2007-0-5-46-50 Zobrazit plný text záznamu