Retrospective analysis of HDFN due to ABO incompatibility in a single institution over 6 years

Autor: Antonella Matteocci, E. Buffone, Luca Pierelli, A. De Rosa
Rok vydání: 2018
Předmět:
Zdroj: Transfusion Medicine. 29:197-201
ISSN: 0958-7578
DOI: 10.1111/tme.12512
Popis: Objectives To study the rate of ABO haemolytic anaemia of fetus and newborn (HDFN) in one institution over 6 years. Background ABO major incompatibility between mothers and their newborns occurs in about 10% of births. So, mothers with an O blood group may form IgG-class antibodies against A and B antigens, which could pass across the placenta and lead to a variable degree of HDFN in the newborn. Methods At our institution, we have reviewed data regarding ABO-based HDFN in the last 6 years. Results We found that, in 28 089 deliveries, an ABO major incompatibility between mothers and newborns occurs in 11% of cases, with 72% of O/A and 28% of O/B incompatibility. In turn, 23% of these newborns had an eluate-confirmed positive direct antiglobulin test [DAT; 74% (511) were due to anti-A and 26% (179) to anti-B], with 1·0% requiring invasive treatments (exchange transfusion or intravenous immunoglobulin). Overall, 2·5% of the total newborns had a positive DAT for an anti-A or anti-B antibody, and 0·11% required invasive treatment in addition to phototherapy for their HDFN. Conclusions Serological ABO HDFN is a relatively frequent event when an O-A/O-B incompatibility between mothers and their newborn occurs and, in most cases, translates into a self-limiting disease, with a small number of newborns requiring invasive treatments. The DAT test, although not predictive of disease severity, appears to be a useful tool to monitor babies born from O-A/O-B-incompatible pregnancies and to identify those who may require treatment.
Databáze: OpenAIRE
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