Prospects of the nasal spray in first aid tools for acute poisoning
| Autor: | V. L. Rejniuk, A. I. Golovko, Yu. Yu. Ivnitsky, M. B. Ivanov, K. A. Krasnov |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Injectable Dosage Form Medical device business.industry medicine.medical_treatment Chemical destruction Dosage form Acute toxicity 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Nasal spray Anesthesia Systemic administration medicine business Pharmaceutical Substances 030217 neurology & neurosurgery |
| Zdroj: | Toxicological Review. :4-10 |
| ISSN: | 0869-7922 |
| DOI: | 10.36946/0869-7922-2020-2-3-9 |
| Popis: | The purpose of this review is to substantiate approaches for improving first aid in acute poisoning. Early administration of medical agents to the victims is advisable, but in injectable dosage form is problematic. An alternative is a nasal spray – dosage form that is suitable for systemic administration of pharmaceutical substances with small molecular weight (up to 1000 Da) and moderate hydrophilicity (log Poctanol/water ≥ 0), and a single dose of which can be contained in volume of up to 0, 3 ml. These criteria are met by the number of pharmaceutical substances used for the treatment of acute poisoning with substances that can form foci of mass destruction. This defines the perspective of nasal sprays as a medical device that allows to speed up, simplify and make it safer to use drugs when providing first aid in the centers of mass chemical destruction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|