THE T-CELL IMMUNITY IN CHILDREN WITH MEGALOTHYMUS
| Autor: | P. D Vaganov, Margarita Nikonova, E. T Mandzhieva, Almira D. Donetskova, E. Yu Yanovskaya |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Medical Journal of the Russian Federation. 23:298-302 |
| ISSN: | 2412-9100 0869-2106 |
| DOI: | 10.18821/0869-2106-2017-23-6-298-302 |
| Popis: | The indices of T-cell immunity are decreased in children of early age with megalothymus: content of T-cells (CD3+), Т-helpers (СD4+ Т-cells), cytotoxic Т-lymphocytes (СD8+ Т-cells), regulatory Т-cells (CD4+CD25hi) and also activated Т-lymphocytes (CD4+CD25lo и CD3+HLA-DR+). The increasing of expression of alterations was observed as degree of megalothymus was progressing. The only exclusion were regulatory T-cells. Their level was decreased under megalothymus degree I and II and was closer to indices of age standard under megalothymus degree III. Also, it was demonstrated that capacity of T-cells to differentiation to cytokine-producing cells type Th1 and Th2 increases as far as increases expression of megalothymus. However, this process remains within framework inherent to comparison group. The T-lymphopenia under megalothymus is conjugated with decreasing of emigration of T-cells from thymus to peripheral section of immune system. These alterations bring on deficiency of T-cell chain of immune system and can favor manifestation of its incapacity especially in conditions of increased load under effect of pathogens. |
| Databáze: | OpenAIRE |
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