The pulmonary administration route: Advantages and challenges
| Autor: | Prabakaran Selvakani, Mariappan Rajan, S. Sakthivel Murugan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Tuberculosis Lung Lung deposition business.industry Human immunodeficiency virus (HIV) Conventional treatment medicine.disease_cause medicine.disease Health problems medicine.anatomical_structure Drug delivery medicine Distribution (pharmacology) business Intensive care medicine |
| DOI: | 10.1016/b978-0-12-819985-5.00007-3 |
| Popis: | For millions of years, significant health problems in human beings have originated from the dominance of tubercle bacillus (TB) or tuberculosis (TB). Today, it remains a considerable health problem globally next to the human immunodeficiency virus (HIV). Conventional treatments fail due to the insufficient compliance of patients and multidrug-resistant tuberculosis. In this chapter, the possible attacking sites of TB in the body as well as its transmission, mechanism, pathogenesis, and current therapies are discussed. We discuss enhancing the efficient treatment of TB through the advanced system of pulmonary drug delivery as well as the particles deposited in the lungs and this mechanism. Moreover, we focus on the factors affecting the lung deposition of drugs and lung drug delivery devices and particles. It is interesting that the distribution of therapeutic agents straightforwardly to the lungs is a more potent therapy than conventional treatment because in the lung delivery method, the anti-TB drugs will be delivered to the site where the bacteria are growing. The efficiency of various lung delivery systems such as liposomes, proliposomes, lipospores, and nanoparticles are increased by the entrapment of anti-TB drugs, and they can deliver the drugs into the lungs in a controlled manner. This shows that pulmonary drug delivery can be superior to conventional therapy. The advantages and factors affecting pulmonary drug delivery are also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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