Histopathological analysis and demonstration of EBV and HIV p-24 antigen but not CMV expression in labial minor salivary glands of HIV patients affected by diffuse infiltrative lymphocytosis syndrome
| Autor: | John J. Sauk, Helen Rivera, John C. Papadimitriou, Sleygh Castillo Castillo, Hessam Siavash, Nikolaos G. Nikitakis |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology Ductal cells Diffuse infiltrative lymphocytosis syndrome virus diseases Biology medicine.disease medicine.disease_cause Asymptomatic Epstein–Barr virus Pathology and Forensic Medicine Parotid gland Atrophy medicine.anatomical_structure stomatognathic system Otorhinolaryngology medicine Periodontics Immunohistochemistry Histopathology Oral Surgery medicine.symptom |
| Zdroj: | Journal of Oral Pathology & Medicine. 32:431-437 |
| ISSN: | 0904-2512 |
| DOI: | 10.1034/j.1600-0714.2003.00061.x |
| Popis: | Background: The diffuse infiltrative lymphocytosis syndrome (DILS) in HIV patients is characterized by the persistence of CD8-circulating lymphocytes and lymphocytic infiltration, predominantly in salivary glands. Methods: We examined seven HIV-positive patients with bilateral parotid enlargement and sicca symptoms. Minor labial salivary gland biopsies were performed in all patients and submitted for histopathological analysis and immunohistochemistry for CD4, CD8, cytomegalovirus (CMV), LMP–EBV protein, and HIV p-24 protein. Results: In all cases, lymphocytic infiltration of the minor salivary glands, mainly periductal, was found. Acinar atrophy, ductal ectasia, and mild to moderate fibrosis were also observed. We noticed strong immunohistochemical reaction for LMP–EBV and p-24 proteins in ductal cells in all cases, while staining for CMV was consistently negative. The lymphocytes were positive for CD8, but consistently negative for CD4. Conclusions: A role of Epstein–Barr virus (EBV) and HIV, but not CMV, in the pathogenesis of DILS, is suggested by our immunohistochemical findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text