Rapid high-performance liquid chromatographic measurement of venlafaxine and O-desmethylvenlafaxine in human plasma

Autor:	F. Péhourcq, F Dumora, Christian Jarry, K Titier, M Matoga
Rok vydání:	2001
Předmět:	Chromatography Metabolite Venlafaxine General Chemistry Reversed-phase chromatography High-performance liquid chromatography Acute toxicity Reuptake chemistry.chemical_compound chemistry medicine Antidepressant Quantitative analysis (chemistry) medicine.drug
Zdroj:	Journal of Chromatography B: Biomedical Sciences and Applications. 760:213-218
ISSN:	0378-4347
DOI:	10.1016/s0378-4347(01)00270-5
Popis:	Venlafaxine, a second-generation antidepressant, acts by inhibition of the reuptake of presynaptic noradrenaline and serotonin. The main metabolite, O-desmethylvenlafaxine was found biologically active. For toxicological purpose, a rapid specific and accurate RP-HPLC assay was developed for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma. A linear response was observed over the concentration range 0.2–4 μg/ml. A good accuracy (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::efcd0fc8b97d2f4017f0a80f76e9a1f8 https://doi.org/10.1016/s0378-4347(01)00270-5 Zobrazit plný text záznamu